Methods for evaluation packet delay distribution of ows using Expedited Forwarding PHB, Journal of Telecommunications and Information Technology, 2004, nr 2

The paper regards problem of providing statistical performance guarantees for real-time flows using Expedited Forwarding Per Hop Behavior (EF PHB) in IP Differentiated Services networks. Statistical approach to EF flows performance guarantees, based on calculation of probability that end-to-end packet delay is larger than certain value, allows larger network utilization than previously proposed deterministic approach. In the paper different methods of packet delay distribution evaluation are presented and compared. Considered cases comprise evaluation of delay distribution models for the core network and evaluation of end-to-end packet delay in the network consisted of edge node and chain of core nodes. Results obtained with aid of analytical models are compared with simulation results

The Realization of NGN Architecture for ASON/GMPLS Network, Journal of Telecommunications and Information Technology, 2011, nr 3

For the last decades huge efforts of telecommunication, Internet and media organizations have been focusing on creating standards and implementing one common network delivering multimedia services – Next Generation Network. One of the technologies which are very likely to be used in NGN transport layer is ASON/GMPLS optical network. The implementation of ASON/GMPLS technology using open source software and its results are the subject of this paper. The ASON/GMPLS architecture and its relation to the proposed ITU-T NGN architecture are described. The concept, functional structure and communication among architecture elements as well as the implementation of laboratory testbed are presented. The results of functional tests confirming proper software and testbed operation are stated

Streaming Real-time Data in Distributed Dispatcher and Teleinformation Systems for Visualization of Multimedia Data of the Border Guard

Surveillance of the sea borders is a very important task for the Border Guard. Monitoring of country maritime border is an important task of the Border Guard. This task can be facilitated with the use of the technology enabling gathering information from distributed sources and its supervision and visualization. This task can be accomplished using a technology that allows to collect information from distributed sensors of different types, unify the collected information, and present the synchronized data. The system presented in the paper is an extension and enhancement of the previously developed distributed map data exchange system. The added functionality allows to supplement the map data with multimedia (telephone and radio calls, video (cameras), photos, files, SMS/SDS) and presentation of current and archival situation on a multi-display screen in the Events Visualization Post. In the paper, the system architecture, functionality and main system elements are described and supported with preliminary analysis and test results

Mechanical thrombectomy in acute stroke – Five years of experience in Poland

Objectives Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland. Methods and results We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures. Results Most of the CSCs (74%) were founded at University Hospitals and most (65.2%) work round the clock. In 78.3% of them, the working teams are composed of neurologists and neuro-radiologists. All CSCs perform CT and angio-CT before MT. In total 586 patients were subjected to MT and data from 531 of them were analyzed. Mean time laps from stroke onset to groin puncture was 250±99min. 90.3% of the studied patients had MT within 6h from stroke onset; 59.3% of them were treated with IV rt-PA prior to MT; 15.1% had IA rt-PA during MT and 4.7% – emergent stenting of a large vessel. M1 of MCA was occluded in 47.8% of cases. The Solitaire device was used in 53% of cases. Successful recanalization (TICI2b–TICI3) was achieved in 64.6% of cases and 53.4% of patients did not experience hemorrhagic transformation. Clinical improvement on discharge was noticed in 53.7% of cases, futile recanalization – in 30.7%, mRS of 0–2 – in 31.4% and mRS of 6 in 22% of cases. Conclusion Our results can help harmonize standards for MT in Poland according to international guidelines

Osimertinib – effective treatment of NSCLC with activating EGFR mutations after progression on EGFR tyrosine kinase inhibitors

Non-small cell lung cancer (NSCLC) driven by activating mutations in epidermal growth factor receptor (EGFR) constitutes up to 10% of NSCLC cases. According to the NCCN recommendations, all patients (with the exception of smoking patients with squamous cell lung cancer) should be screened for the presence of activating EGFR mutations, i.e. deletion in exon 19 or point mutation L858R in exon 21, in order to select the group that benefits from EGFR tyrosine kinase inhibitors (EGFR TKIs) treatment. Among approved agents there are the 1st generation reversible EGFR TKIs, erlotinib and gefitinib, and the 2nd generation irreversible EGFR TKI, afatinib. The objective response rates to these drugs in randomised clinical trials were in the range of 56–74%, and median time to progression 9–13 months. The most common determinant of resistance to these drugs is the clonal expansion of cancer cells with T790M mutation (Thr790Met) in exon 20 of EGFR. Osimertinib (Tagrisso™), a 3rd generation, irreversible EGFR tyrosine kinase inhibitor, constitutes a novel, highly efficacious treatment for NSCLC patients progressing on EGFR TKIs with T790M mutation confirmed as the resistance mechanism. Resistance mutation can be determined in tissue or liquid biopsy obtained after progression on EGFR TKIs. Osimertinib has a favourable toxicity profile, with mild rash and diarrhoea being the most common. In this article, we present three cases that were successfully treated with osimertinib after progression on 1st and 2nd generation EGFR TKIs

Mapserver – Information Flow Management Software for The Border Guard Distributed Data Exchange System

In this paper the architecture of the software designed for management of position and identification data of floating and flying objects in Maritime areas controlled by Polish Border Guard is presented. The software was designed for managing information stored in a distributed system with two variants of the software, one for a mobile device installed on a vessel, an airplane or a car and second for a central server. The details of implementation of all functionalities of the MapServer in both, mobile and central, versions are briefly presented on the basis of information flow diagrams

Mechanical thrombectomy in acute stroke : five years of experience in Poland

Objectives: Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland. Methods and results: We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures. Results: Most of the CSCs (74%) were founded at University Hospitals and most (65.2%) work round the clock. In 78.3% of them, the working teams are composed of neurologists and neuro-radiologists. All CSCs perform CT and angio-CT before MT. In total 586 patients were subjected to MT and data from 531 of them were analyzed. Mean time laps from stroke onset to groin puncture was 250 99 min. 90.3% of the studied patients had MT within 6 h from stroke onset; 59.3% of them were treated with IV rt-PA prior to MT; 15.1% had IA rt-PA during MT and 4.7% - emergent stenting of a large vessel. M1 of MCA was occluded in 47.8% of cases. The Solitaire device was used in 53% of cases. Successful recanalization (TICI2b–TICI3) was achieved in 64.6% of cases and 53.4% of patients did not experience hemorrhagic transformation. Clinical improvement on discharge was noticed in 53.7% of cases, futile recanalization - in 30.7%, mRS of 0–2 - in 31.4% and mRS of 6 in 22% of cases. Conclusion: Our results can help harmonize standards for MT in Poland according to international guideline